4-Methyl-3-[4-(3-pyridyl)pyrimidin-2-yloxy]aniline
نویسندگان
چکیده
In the title compound, C(16)H(14)N(4)O, there are inter-molecular N-H⋯N hydrogen bonds which may be effective in stabilizing the crystal. The title compound is an important medicament and is used in the synthesis of anti-tumour drugs.
منابع مشابه
tert-Butyl N-{4-methyl-3-[4-(3-pyridyl)pyrimidin-2-yloxy]phenyl}carbamate
In the mol-ecule of the title compound, C(21)H(22)N(4)O(3), the pyrimidine ring is oriented at dihedral angles of 0.51 (3) and 50.76 (3)° to the pyridine and benzene rings, respectively. In the crystal structure, inter-molecular N-H⋯N hydrogen bonds link the mol-ecules into centrosymmetric dimers, forming R(2) (2)(24) ring motifs; the dimers are linked by inter-molecular C-H⋯O hydrogen bonds in...
متن کاملAcetato(N-[(E)-1-(6-methyl-2-pyridyl)methylidene]-2-{2-[(E)-1-(6-methyl-2-pyridyl)methylideneamino]phenethyl}aniline)nickel(II) perchlorate
In the title complex, [Ni(CH(3)COO)(C(28)H(26)N(4))]ClO(4), the Ni(II) atom is coordinated by two imine N atoms and two pyridine N atoms of the N-[(E)-1-(6-methyl-2-pyrid-yl)methyl-idene]-2-(2-[(E)-1-(6-methyl-2-pyrid-yl)methyl-idene-amino]-pheneth-yl)aniline donor ligand and two O atoms of the acetate ion in a distorted octa-hedral coordination. The average Ni-N and Ni-O bond lengths are 2.131...
متن کامل2-Chloro-8-methyl-3-[(pyrimidin-4-yloxy)methyl]quinoline
In the title compound, C(15)H(12)ClN(3)O, the quinoline ring system is essentially planar, with a maximum deviation of 0.017 (1) Å. The crystal packing is stabilized by π-π stacking inter-actions between the quinoline rings of adjacent mol-ecule, with a centroid-centroid distance of 3.5913 (8) Å. A weak C-H⋯π contact is also observed between mol-ecules.
متن کامل3-{[4-(4-Pyridyl)pyrimidin-2-yl]sulfanylmethyl}benzoic acid
The title compound, C(17)H(13)N(3)O(2)S, was prepared by reaction of 4-(4-pyrid-yl)pyrimidine-2-thiol with 3-(bromo-meth-yl)benzoic acid under basic conditions. Each pair of mol-ecules is mutually linked via O-H⋯N hydrogen bonds, forming a dimer. The packing of the dimers is stablized by C-H⋯π inter-actions involving the methyl-ene unit of the -CH(2)S- linkage and benzene rings.
متن کاملTetraaquabis{2-[4-(3-pyridyl)pyrimidin-2-ylsulfanyl]acetato}manganese(II) dihydrate
In the title compound, [Mn(C(11)H(8)N(3)O(2)S)(2)(H(2)O)(4)]·2H(2)O, the Mn(II) ion lies on an inversion centre and is coordinated by four water mol-ecules in equatorial positions and two N atoms from two 2-[4-(3-pyrid-yl)pyrimidin-2-ylsulfan-yl]acetate ligands in the axial positions. The water mol-ecules, including the uncoordinated water mol-ecules, and the acetate O atoms are involved in O-H...
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